Cartoon Network Crossover Crisis: Animation Annihilation DBG is a standalone deck-building game where you build your own card decks. You can also combine it with the Cartoon Network Crossover Crisis Deck Building Game set.

The cards feature artwork of classic characters from Cartoon Network animated series, such as The Powerpuff Girls, Adventure Time, Uncle Grandpa, Cow and Chicken, The Grim Adventures of Billy & Mandy, or Ed, Edd n Eddy.

Animation Annihilation also includes 6 new oversized characters with a new ability: Wonder. This ability lets you play the top card of the main deck, place it in the lineup, and buy it immediately.

The game is in English.